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1 article(s) from Manz, Andreas

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

Nashrawan Lababidi,
Valentin Sigal,
Aljoscha Koenneke,
Konrad Schwarzkopf,
Andreas Manz and
Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

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Figure 1: The effect of the flow rate ratio (0.05–1.0) and flow speed of the aqueous phase (10–100 µL/min) on...

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Figure 2: Illustration the impact of increasing the flow rate ratio on the mixing pattern and the geometry of...

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Figure 3: Effect of different PLGA concentrations (1–10 mg/mL) on NP size and PDI at different flow rate rati...

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Figure 4: Effect of adjusting the diameter of the focusing channel (100 µm, 180 µm and 280 µm) on NP size and...

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Figure 5: Effect of stabilizer concentration (0.1% and 1% of F68) on NP size and size distribution compared t...

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Figure 6: Effect of solvent nature (acetonitrile (ACN), dimethyl sulfoxide (DMSO) and acetone) on NP size and...

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Figure 7: Effect of using different mixing channel lengths (1 cm, 2 cm and 5 cm) on the NP size and size dist...

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Figure 8: Illustration of nucleation and growth mechanism of nanoprecipitation along the focus mixing channel...

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Figure 9: Comparison of the NP size after encapsulation using different approaches, namely the microfluidic s...

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Figure 10: Encapsulation efficiency of curcumin using the different approaches.

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Figure 11: Size and size distribution of nanoparticles stabilized with different types of Pluronic before and ...

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Figure 12: xz-micrographs taken in confocal laser scanning microscopy study of the penetration of differently ...

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Scheme 1: Sketch of the reaction scheme for PLGA labelling with rhodamine B. The carboxy group of the fluores...

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Figure 13: Design and flow pattern of the microfluidic system.

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Published 19 Nov 2019

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